Endocrine Abstracts

Purposes: To investigate effects of combination therapy with fenofibrate and α-lipoic acid (ALA) on atherogenic dyslipidemia, which determines the residual vascular risk and endothelial dysfunction, levels of proinflammatory mediators in patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 42 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included hi...

Purposes: To investigate the effects of α-lipoic acid (ALA) on diabetic dyslipidemia, endothelial dysfunction, levels of adiponectin and proinflammatory mediators in combination therapy of patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 40 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included history of IHD (7.2±2.3 years), T2DM (4.7&#177...

Introduction: Weight gain and obesity promote metabolic syndrome, diabetes and other cardiovascular risk factors. Weight loss achieved by lifestyle change can limit progression of cardiovascular risk factors. What is the current approach to obesity in general practice and can a nurse- led programme result in clinically beneficial weight change?Methods: The Counterweight Programme has developed a model of best practice for obesity management in UK primary...

The aim of this study is evaluating body composition in postmenopausal women depending on presence of vertebral fractures in their anamnesis.Materials and methods: We’ve examined 144 postmenopausal women aged 50–83 years (mean age – 62.9±0.7 years; mean height – 160.6±0.5 cm; mean weight – 71.9±1.2 kg). The patients were divided into two groups: group A – women without vertebral fractures (n=82), group ...

Neurokinin B has been traditionally regarded as a neuropeptide being confined to the CNS, with no peripheral expression. This situation was the cause of some confusion as its preferred receptor (NK3R) is found mainly on peripheral organs such as the portal vein, mesenteric vessels and the heart with relatively low levels in the brain. In 2000 our laboratory reported the placenta to be an abundant peripheral endocrine source of NKB, giving rise to significant plasma concentrati...

The pregnancy associated plasma proteins (PAPP) -A, -B, -C and -D were first isolated from pregnancy serum in 1974. Since, these proteins have been re-characterised; PAPP-B and PAPP-C are now known as pregnancy-specific beta-1 glycoproteins and PAPP-D as placental lactogen. PAPP-A was subsequently found to be a member of the metzincins family of metalloproteases. Recently we have identified a full-length cDNA encoding the preproprotein of pregnancy associated plasma protein-E ...

In recent years there has been an increase in the incidence and prevalence of overweight and obesity around the world. Overweight and obesity are more common among people living with type 1 diabetes (T1D) than originally anticipated1 . The SEARCH study found 21% of T1D patients are overweight2 and 12.6%3 are obese. The T1D Exchange Study found an obesity rate of 13.1% in adolescents4 . The DCCT-EDIC Study found that the obesity preva...

In the 27 families with FNAH the onset of hyperthyroidism varies from 18 months to 60 years. Also the manifestation of goiters is variable in these families.A 74 year old women first presented at the age of 69 years in 9/2006 with tachyarrythmia and hypertension. After the initial treatment of her hypertension and oral anticoagulation for her intermittant atrialfibrilation 3/2007 a thyroid workup revealed a suppressed TSH of 0.029 (normal< 0.4 mU/l) ...

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).Materials and method: Thirty-two women with PCOS (age: 23.4–4.6 years; BMI: 23.8–4.8 kg/m2), similar age and BMI have features 30 healthy womens c...

Background: Hypopituitarism after cranial radiotherapy for non-pituitary tumors is well recognized. However structured endocrine assessments are not incorporated into routine clinical practiceAim of the study: To evaluate pituitary function in adult patients irradiated for non-pituitary tumors at our centerPatients and Methods: Cross-sectional evaluation of pituitary function of all available patients treated with irradiation at ou...